GIAB Benchmark Validator Skill
SkillDev toolsGenome in a Bottle benchmark validation skill for pipeline accuracy assessment
Use GIAB Benchmark Validator Skill in Claude, ChatGPT or Ahel Desktop
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Then ask your AI: use the GIAB Benchmark Validator Skill
Details
Instructions available. Your AI can read the instructions. Execution depends on the setup they require.
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What this skill tells your AI
The instructions your AI receives, as published by a5c-ai/babysitter in library/specializations/domains/science/bioinformatics/skills/giab-benchmark-validator/SKILL.md and read by Ahel’s review.
Purpose
Enable Genome in a Bottle benchmark validation for pipeline accuracy assessment.
Capabilities
- Truth set comparison
- hap.py/vcfeval execution
- Sensitivity/specificity calculation
- Stratified performance metrics
- Difficult region analysis
- Validation report generation
Usage Guidelines
- Use appropriate GIAB reference samples
- Compare against truth sets with hap.py
- Calculate sensitivity and specificity
- Stratify by region type and variant class
- Analyze performance in difficult regions
- Generate comprehensive validation reports
Dependencies
- hap.py
- vcfeval
- GIAB resources
Process Integration
- Analysis Pipeline Validation (pipeline-validation)
- Whole Genome Sequencing Pipeline (wgs-analysis-pipeline)
Signals
- GitHub stars
- 2k
- Forks
- 113
- Last commit
- Sep 2026
Advanced
- Item type
- skill
- Key
giab-benchmark-validator- Source
- github.com/a5c-ai/babysitter