TMB-MSI Calculator Skill
SkillDev toolsTumor mutation burden and microsatellite instability calculation skill for immunotherapy biomarkers
Use TMB-MSI Calculator Skill in Claude, ChatGPT or Ahel Desktop
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Then ask your AI: use the TMB-MSI Calculator Skill
Details
Instructions available. Your AI can read the instructions. Execution depends on the setup they require.
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Add Ahel to your AI once: Claude, ChatGPT, Cursor, Claude Code or Codex. Then ask it to use this.
What this skill tells your AI
The instructions your AI receives, as published by a5c-ai/babysitter in library/specializations/domains/science/bioinformatics/skills/tmb-msi-calculator/SKILL.md and read by Ahel’s review.
Purpose
Calculate tumor mutation burden and microsatellite instability for immunotherapy biomarker assessment.
Capabilities
- TMB calculation from VCF
- MSI status determination
- Neoantigen prediction
- HLA typing integration
- Biomarker thresholds
- Clinical report generation
Usage Guidelines
- Calculate TMB with appropriate normalization
- Determine MSI status accurately
- Predict neoantigens for immunotherapy
- Apply clinical thresholds for reporting
- Generate actionable reports
- Document methodology and thresholds
Dependencies
- TMBcat
- MSIsensor2
- MANTIS
Process Integration
- Tumor Molecular Profiling (tumor-molecular-profiling)
Signals
- GitHub stars
- 2k
- Forks
- 113
- Last commit
- Sep 2026
Advanced
- Item type
- skill
- Key
tmb-msi-calculator- Source
- github.com/a5c-ai/babysitter